Emma Coronel Aispuro, the wife of the notorious Mexican drug lord known as El Chapo, is set to plead guilty this week to charges of helping her husband run his multibillion-dollar empire and then, after one of his arrests, escape in dramatic fashion from a high-security Mexican prison, according to a person familiar with the case.

Ms. Coronel, 31, is expected to appear on Thursday morning in Federal District Court in Washington to enter her plea. She was taken into custody in February at Dulles International Airport, near Washington, after a nearly two-year investigation by U.S. law enforcement officials into her role as an accomplice to her husband, whose real name is Joaquín Guzmán Loera.

Mr. Guzmán, a onetime co-leader of the Sinaloa drug cartel, was convicted in 2019 at a federal trial in Brooklyn and is now serving life sentence in the so-called Supermax in Colorado, the most secure federal prison in the United States. Ms. Coronel, his third — or possibly fourth — wife, had remained free even after a jury found him guilty, traveling between the United States and Mexico until her own arrest.

When she taken into the custody by the F.B.I., there was intense speculation over whether Ms. Coronel, a dual U.S.-Mexican citizen, would seek to offer the government information on her husband’s allies, relatives and business partners in exchange for a lighter sentence. But her plea agreement with prosecutors in Washington does not require her to cooperate with the U.S. authorities, the person familiar with the case said.