In a sharp break with the Trump administration, President-elect Joseph R. Biden Jr. intends to release nearly all available doses of the coronavirus vaccine soon after he is inaugurated, rather than hold back millions of vials to guarantee second doses will be available.

The decision is part of an aggressive effort to “to ensure the Americans who need it most get it as soon as possible,” the Biden transition team said on Friday. The vaccination plan, to be formally unveiled next week, also will include federally run vaccination sites in places like high school gyms and sports stadiums, and mobile units to reach high-risk populations.

The president-elect has vowed to get “at least 100 million Covid vaccine shots into the arms of the American people” during his first 100 days in office.

The decision to release the vast majority of vaccine doses set off a sharp debate among public health experts. The two vaccines that have received emergency approval each require two doses, and the Trump administration has so far been holding back about half of its supply to ensure that booster doses will be available for those already inoculated.

out strongly against changing the dosing schedule,

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